Orion Peptides
Popular
buy Thymosin Alpha-1 –5mg

,

Thymosin Alpha-1 – 5mg

| Third-Party Tested | 99% Purity | COA Available | Research Use Only

Thymosin Alpha-1 is a synthetic 28-amino acid peptide derived from thymosin fraction 5 of the bovine thymus gland.

$53.00

0 out of 5 · 0 ratings
Be the first to rate this compound:

17 in stock

17 in stock

Bulk Pricing – Save More

3
Buy 3 units 5% OFF
$50.35 each Total: $151.05 (Save $7.95)
5
Buy 5 units 10% OFF
$47.70 each Total: $238.50 (Save $26.50)
10
Buy 10 units 15% OFF
$45.05 each Total: $450.50 (Save $79.50)
Clear selection
  • ≥99% (HPLC)
  • Third-Party Tested
  • Fast Shipping
  • Research Grade

Buy Thymosin Alpha-1 – 5mg 

Thymosin Alpha-1 is a synthetic 28-amino acid peptide derived from thymosin fraction 5 of the bovine thymus gland. One of the most well-researched immune-modulating peptides in laboratory and preclinical studies. Its role in T-cell differentiation and activation cytokine regulation is known to support immune system function as a whole.

Important Research Disclaimer:

Thymosin Alpha-1 5mg is an investigational novel drug used only for research purposes. It is not approved by the F.D.A. for human consumption, immune therapy, vaccine enhancement or any other medical use. This compound is for researchers use only and not intended for diagnostic or therapeutic purposes. Not for individual or private use.

Thymosin Alpha-1 Molecular Structure and Chemical Properties

Thymosin Alpha-1 (Tα1), also known as Thymalfasin, is a synthetic or naturally occurring peptide containing 28 amino acids. It has a linear structure with an acetyl group attached to its N-terminus. Researchers study Thymosin Alpha-1 for its role in immune cell signaling, T-cell regulation, and other immune-related pathways.

Thymosin Alpha-1 Chemical Properties Table

Property Correct Information
Compound Name Thymosin Alpha-1
Alternative Names Thymalfasin, Tα1, TA-1
Molecular Formula C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight 3,108.3 g/mol
CAS Number 62304-98-7
PubChem CID 16130571
Amino Acid Length 28 amino acids
One-Letter Sequence SDAAVDTSSEITTKDLKEKKEVVEEAEN
Full Sequence Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
Peptide Classification Synthetic or naturally occurring polypeptide
Peptide Structure Linear
N-Terminal Modification Acetylated (Ac–)
C-Terminal Group Free carboxyl group (–COOH)
Disulfide Bonds None
Research Applications Immune cell signaling, T-cell activity, and immune regulation
The molecular formula, weight, sequence, and chemical identifiers are documented in PubChem.

Thymosin Alpha-1 vs Thymosin Beta-4

Both Thymosin Alpha-1 and Thymosin Beta-4 are thymic peptides but serve very different purposes in research:
  • Thymosin Alpha-1 is mostly an immune modulator. It improves cytotoxic T cell maturation, cytokine balance, and adaptive immunity. It has been extensively studied in immune senescence, viral response, and models of immune restoration.
  • In regenerative medicine and injury restitution models, Thymosin Beta-4 has primarily been studied for its abilities in actin-sequestering, wound healing, tissue remodelling and repairing activities, angiogenesis promotion & anti-inflammatory properties.
Whereas Thymosin Beta-4 acts via regulation of the cytoskeleton and tissue repair, Thymosin Alpha-1 is used to study restoration of the immune system, T-cell function, and adaptive immunity modulation in aging models or models with borderline immune function.

Research-Based Benefits of Thymosin Alpha-1( Only Applicable to Research Environment)

Thymosin Alpha-1 has been studied in laboratory and preclinical research for these major areas:

1. T-Cell Maturation and Function Agonist

Thymosin Alpha-1 promotes functional T-cell creation from immature T-cell progenitors. It strengthens T-cell receptor signaling and increases IL-2 receptor expression, promoting enhanced adaptive immune responses in experimental models.

2. Modulation of Cytokine Production

The studies show Thymosin Alpha-1 enhances production of IL-2, IFN-γ, and other Th1 cytokines and aids in balancing the Th1/Th2 responses. This makes it useful for research in immune regulation and inflammatory control.

3. Supports Natural Killer (NK) Cell Activity

Thymosin Alpha-1 has been shown to augment NK cell activity and cytotoxicity, and provide better innate immune surveillance in multiple models of immune challenge.

4. Promising Role in Immunosenescence and Ageing Studies

It is known that in aging animal models, Thymosin Alpha-1 has been shown to reverse age-related decline of T-cell function, thymic output, and overall immune competence.

5. Research into Antiviral and Immune Defense

Thymosin Alpha-1 is also commonly employed as an experimental treatment in research on immune responses to viral infections, for its effects as a vaccine adjuvant, and to support adaptive immunity in immunocompromised or stressed models.

6. Restoration of Immune Balance

It has shown potential in correcting immune dysregulation and supporting balanced immune responses in models of chronic inflammation or immune exhaustion. Note: All stated benefits are from preclinical, animal, or early-phase research studies. They are not therapeutic claims. Safety and effectiveness in humans have not yet been determined for the research peptide form.

Compound Specifications – Thymosin Alpha-1 5mg

Peptide: Thymosin Alpha-1 In the newest formulation: 5 mg lyophilized powder in a vial Purity: ≥99% (HPLC) (Research Grade) Pharmaceutical Form: Lyophilized (for better stability) Use: For laboratory research use only Thymosin Alpha-1 5mg is a selective and highly useful research instrument for researchers interested in the areas of T-cell biology, cytokine signaling, immune modulation, immune senescence, antiviral responses or thymic function.

References

  1. Goldstein AL, et al. Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc Natl Acad Sci USA. 1977;74(2):725-729. 
  1. Tuthill CW, et al. Thymosin alpha1: a peptide for all seasons. Ann N Y Acad Sci. 2007;1112:1-13.  
  2. Romani L, et al. Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance. Ann N Y Acad Sci. 2010;1194:1-13.  
  1. Serafino A, et al. Thymosin alpha1 as a stimulator of innate immunity and a modulator of adaptive immunity. Int Immunopharmacol. 2014;19(2):362-368.  
  1. Garaci E, et al. Thymosin alpha1: from bench to bedside. Ann N Y Acad Sci. 2007;1112:225-234.  
   https://pubmed.ncbi.nlm.nih.gov/17947586/
  1. Goldstein AL, et al. Thymosins: clinical and biological properties. Expert Opin Biol Ther. 2009;9(5):599-608.  

Research Use Only

This compound is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Molecular Formula C129H215N33O55
Molecular Mass 3108.3 g/mol
Monoisotopic Mass 3106.5041281 Da
Polar Area 1460 Ų
Complexity 7190
XLogP -24
Heavy Atom Count 217
Hydrogen Bond Donor Count 49
Hydrogen Bond Acceptor Count 59
Rotatable Bond Count 111
CID 16130571
InChI InChI=1S/C129H215N33O55/c1-18-59(10)98(159-114(201)76(36-42-91(181)182)146-120(207)83(53-164)154-121(208)84(54-165)155-127(214)99(63(14)166)160-118(205)80(51-94(187)188)152-123(210)95(56(4)5)156-104(191)62(13)135-102(189)60(11)137-115(202)78(49-92(183)184)151-119(206)82(52-163)138-66(17)169)125(212)161-101(65(16)168)128(215)162-100(64(15)167)126(213)147-70(30-22-26-46-133)109(196)150-79(50-93(185)186)117(204)149-77(47-55(2)3)116(203)142-69(29-21-25-45-132)108(195)144-73(33-39-88(175)176)110(197)141-67(27-19-23-43-130)106(193)140-68(28-20-24-44-131)107(194)145-75(35-41-90(179)180)113(200)157-97(58(8)9)124(211)158-96(57(6)7)122(209)148-74(34-40-89(177)178)111(198)143-71(31-37-86(171)172)105(192)136-61(12)103(190)139-72(32-38-87(173)174)112(199)153-81(129(216)217)48-85(134)170/h55-65,67-84,95-101,163-168H,18-54,130-133H2,1-17H3,(H2,134,170)(H,135,189)(H,136,192)(H,137,202)(H,138,169)(H,139,190)(H,140,193)(H,141,197)(H,142,203)(H,143,198)(H,144,195)(H,145,194)(H,146,207)(H,147,213)(H,148,209)(H,149,204)(H,150,196)(H,151,206)(H,152,210)(H,153,199)(H,154,208)(H,155,214)(H,156,191)(H,157,200)(H,158,211)(H,159,201)(H,160,205)(H,161,212)(H,162,215)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180)(H,181,182)(H,183,184)(H,185,186)(H,187,188)(H,216,217)/t59-,60-,61-,62-,63+,64+,65+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,95-,96-,97-,98-,99-,100-,101-/m0/s1
InChIKey NZVYCXVTEHPMHE-ZSUJOUNUSA-N
IUPAC Name (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-6-aminohexanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-5-oxopentanoic acid
Smiles CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C

Certificate of Analysis

Quality

Every batch of Thymosin Alpha-1 – 5mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥99%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All compounds undergo independent third-party laboratory testing for quality assurance.

Request COA

Certificate of Analysis documents are available for all compounds. Contact us with your order number to request batch-specific documentation.

Contact Support

COA Lab Tests

Each compound batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the compound meets strict research-grade standards.

⁠Current Batch Test Results
Past Batches Test Results
Search By your Order Number or Batch Number

Storage & Handling

Before Use (Unopened)

  • Store in a refrigerator at 2°C to 8°C (36°F to 46°F)
  • Keep the temperature constant at all times
  • Store in the main refrigerator compartment — avoid the door

After Reconstitution (Liquid Form)

  • Continue storing at 2°C to 8°C (36°F to 46°F)
  • Keep the liquid form refrigerated between doses
  • Return to the refrigerator immediately after each use
  • Do not shake; handle gently to maintain stability

Storage During Travel

  • Keep in original packaging for protection
  • Minimize time outside the proper temperature range
  • Use an insulated cooler pack if traveling for more than 30–60 minutes
  • Return to the refrigerator as soon as you arrive
  • Plan for long trips to avoid temperature fluctuations

After Reconstitution (Liquid Form)

  • Continue storing at 2°C to 8°C (36°F to 46°F)
  • Keep the liquid form refrigerated between doses
  • Return to the refrigerator immediately after each use
  • Do not shake; handle gently to maintain stability

Related Compounds

RT-15mg

RT 15mg

$119.00

Add
TZ 15mg

TZ 15mg

$77.00

Add
5MG TZ Research Vial

TZ 5MG

$44.00

Add
Buy TZ 30mg

TZ 30mg

$148.00

Add
TZ 20mg

TZ 20mg

$104.00

Add
TZ 10mg

TZ 10mg

$55.00

Add

SM 15mg

$69.00

Add
SM 5mg

SM 5mg

$40.00

Add
Buy SM 10mg

SM 10mg

$55.00

Add

RT-5mg

$54.00

Add
Buy RT-10mg

RT-10mg

$81.00

Add
Buy GL P 3 RT 20mg

Buy (RT) 20mg

$145.00

Add
×
On Sale
Out of Stock

Storage

Store at -20°C.
Protect from light and moisture.

View Full Details
Added to cart successfully!

Certificate of Analysis

ORP#00004
Client:
Orion Peptides
Sample:
Thymosin Alpha-1 5mg
Batch:
202602TA5
Tests Requested:
Standard + Endotoxins + Sterility
Appearance:
White Lyophilized Powder in 3mL Vial
Analysis Conducted on:
02/02/2026
Report Issued on:
08/01/2026
Test Method Result Specification  
Identity HPLC-DAD Thymosin Alpha-1 Thymosin Alpha-1 Pass
Purity HPLC-DAD 99.75 >99% by HPLC Pass
Quantity HPLC Analyte Concentration Curve Assay 4.98mg 5mg Pass
Endotoxins LAL ELISA 0.223 EU/mL ≤ 0.5 EU/mL Pass
Sterility Pour Plate No Growth No Growth Pass
Disclaimer: The data contained in this report is representative of the received sample. This analysis is for informational purposes only. The tested substances are intended for research use only and are not approved for human or veterinary use, diagnostic, therapeutic, or clinical applications. All data was obtained under standard laboratory conditions.
QR Verification Code