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Melanotan II (MT‑2) is a synthetic cyclic heptapeptide and an analogue of α‑melanocyte‑stimulating hormone (α‑MSH), a natural neuropeptide from the melanocortin family. First synthesized in the 1980s at the University of Arizona during research on UV‑independent pigmentation,
Melanotan II peptide is supplied as a high‑purity lyophilized powder for laboratory research applications. It functions as a non‑selective melanocortin receptor agonist and is widely studied in preclinical research involving pigmentation pathways, receptor pharmacology, and neuroendocrine signaling. Melanotan II is intended strictly for laboratory and animal research use only and is not approved for human consumption or therapeutic applications.
Melanotan II 10 mg
Melanotan II 10 mg refers to a research vial containing 10 mg of lyophilized synthetic peptide powder. This quantity supports multiple experimental procedures, including receptor binding studies, cell‑based assays, and animal model research. The peptide is commonly supplied in acetate salt form. Vials are typically reconstituted using bacteriostatic or sterile water under sterile laboratory conditions to prepare working research solutions. The 10 mg format provides flexibility for both small‑scale in vitro experiments and extended in vivo investigations.
Melanotan II Research Box
| Research parameter | Reported information |
| Compound | Melanotan II (MT-II) |
| Chemical class | Synthetic cyclic melanocortin peptide |
| Peptide type | Cyclic heptapeptide |
| Parent peptide | α-MSH analogue |
| MC1R reported Ki | ~0.67 nM |
| MC3R reported Ki | ~34 nM |
| MC4R reported Ki | ~6.6 nM |
| MC5R reported Ki | ~46 nM |
| Molecular weight | ~1024.2 Da |
| CAS | 121062-08-6 |
| Research areas | Melanogenesis, receptor pharmacology, neuroendocrine signaling, appetite-related pathways |
| Research status | Investigational / non-approved compound |
Melanotan II Mechanism of Action
In laboratory models, Melanotan II acts as a non‑selective agonist of melanocortin receptors, primarily MC1R, MC3R, MC4R, and MC5R. By mimicking α‑MSH, it binds to these G‑protein‑coupled receptors and activates intracellular signaling pathways, including increased cyclic AMP (cAMP) production associated with melanogenesis.
Key research observations include:
- Activation of MC1R receptors on melanocytes, promoting eumelanin production associated with darker pigmentation.
- Interaction with MC4R pathways linked to appetite regulation, energy balance, and neuroendocrine signaling.
- Additional activity at MC3R receptors involved in metabolic regulation.
This multi‑receptor activity makes MT‑2 useful for studying melanocortin system signaling and receptor dynamics in controlled research environments.
Melanotan II Peptide Sequence
Melanotan II is a cyclic heptapeptide with the following structure:
Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑NH₂ - Ac indicates N‑terminal acetylation for enhanced stability.
- Nle represents norleucine, a non‑natural amino acid substitution.
- A cyclic lactam bridge forms between Asp and Lys residues.
- Molecular formula: C₅₀H₆₉N₁₅O₉
- Molecular weight: ≈1024.2 Da
- CAS number: 121062‑08‑6
The cyclic structure improves resistance to enzymatic degradation, supporting experimental stability in research applications.
Research Background
Melanotan II (MT-II) is a synthetic cyclic heptapeptide developed as an analogue of α-melanocyte-stimulating hormone (α-MSH). Its structure incorporates a lactam bridge that constrains the peptide into a cyclic configuration while retaining the His-D-Phe-Arg-Trp pharmacophore associated with melanocortin receptor activation. Research has characterized MT-II as a potent, non-selective melanocortin receptor ligand and has used it as an experimental tool for investigating melanocortin receptor pharmacology. The compound has been investigated in both in vitro and in vivo experimental systems. Research has particularly focused on melanocortin receptor signaling, pigmentation biology, appetite regulation, sexual behavior, and related neuroendocrine pathways. These studies provide a scientific basis for using MT-II as a research compound for investigating the physiological functions of melanocortin receptors.
Melanotan II Receptor Pharmacology
Melanotan II is characterized as a non-selective agonist across several melanocortin receptor subtypes. Experimental pharmacology has identified activity at MC1R, MC3R, MC4R, and MC5R, making MT-II a useful research tool for examining signaling across the melanocortin receptor family. Reported receptor-binding data illustrate the different pharmacological profiles of the melanocortin receptors. In one compiled dataset, MT-II demonstrated reported Ki values of approximately
0.67 nM at MC1R, 34 nM at MC3R, 6.6 nM at MC4R, and 46 nM at MC5R. These values should be interpreted as experimental receptor-binding measurements rather than clinical potency or dosing recommendations, because assay conditions and receptor systems can influence measured affinity. MC1R is particularly relevant to pigmentation research. Activation of MC1R on melanocytes is associated with intracellular signaling involving cyclic AMP and downstream processes involved in melanogenesis. Experimental studies with melanocortin ligands have demonstrated relationships between receptor activation, cAMP signaling, tyrosinase activity, and melanin production.
Storage and Handling
Melanotan II is supplied as a lyophilized powder for improved stability. Store unopened vials in a cool, dry, and dark environment. Long‑term storage is recommended at −20°C, although short‑term stability may be maintained at 2–8°C when protected from moisture and light. After reconstitution with bacteriostatic or sterile water under sterile laboratory conditions, refrigerate solutions at 2–8°C and use within standard research timelines (typically 3–4 weeks). Avoid repeated freeze‑thaw cycles and exposure to contamination or direct light.
How Much Does Melanotan II 10 mg Cost?
The Melanotan II 10 mg research vial is priced at
$45. All peptides are manufactured in the USA, tested for high purity, and supplied strictly for laboratory research purposes.
Disclaimer
Melanotan II is an investigational research peptide intended solely for in vitro laboratory research and in vivo animal studies. It is not approved by the FDA, EMA, or any regulatory authority for human use, diagnosis, treatment, or supplementation. This compound is classified as a non‑approved substance and may fall under restricted categories such as WADA S0. No claims are made regarding safety or effectiveness in humans. Compounds must be handled only in qualified laboratory environments with proper institutional oversight.
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