Buy Glutathione (10ML) – 600mg| 99% Purity| COA Available
L-Glutathione 600 mg is a pure, lyophilized form of the naturally occurring tripeptide γ-L-glutamyl-L-cysteinyl-glycine. It is one of the most abundant low-molecular-weight thiols in mammalian cells and functions as the primary intracellular antioxidant. It is used to study redox balance, detoxification pathways, and cellular stress responses in research settings. Glutathione also supports investigations on mitochondrial function and age-related oxidative damage. Each vial contains 600 mg of ≥99% pure reduced L-Glutathione. The compound appears as a white lyophilized powder and is manufactured and analytically tested in the United States. This vial size supports in vitro assays, cell culture work, and small-animal protocols.
L-Glutathione is supplied only for laboratory research use and is not intended for human consumption or therapeutic use.
Glutathione 600mg Molecular Formula and Chemical Properties
Glutathione is classified as a tripeptide because it contains three amino acid residues. Its chemical structure includes a cysteine thiol group, which plays an important role in redox reactions.
| Property | Details |
| Compound name | Glutathione 500mg |
| Chemical name | L-Glutathione, reduced |
| Alternative names | GSH, Reduced Glutathione |
| Peptide type | Naturally occurring tripeptide |
| Amino acid sequence | γ-Glu-Cys-Gly |
| Full sequence | γ-L-Glutamyl-L-cysteinyl-glycine |
| Number of amino acids | 3 |
| Molecular formula | C₁₀H₁₇N₃O₆S |
| Molecular weight | 307.33 g/mol |
| CAS number | 70-18-8 |
| PubChem CID | 124886 |
| Redox forms | GSH and GSSG |
| Nominal vial content | 600mg |
| Physical form | Lyophilized powder |
| Research focus | Redox signaling, oxidative stress, glutathione metabolism |
| Intended use | Laboratory research only |
The molecular formula and weight refer to reduced L-glutathione.
Chemical reference: PubChem: Glutathione, CID 124886.
Glutathione Research
L-Glutathione is widely used in biochemical and cellular research. Common applications include:
- Research on antioxidant defense and oxidative stress
- Glutathione S-transferase and Phase II detoxification studies
- Apoptosis pathways and mitochondrial redox balance
- Models of liver injury, aging, and neurodegeneration
- Immune response and inflammation experiments
- Cellular response to toxins and radiation
The 600 mg format allows multiple experiments with minimal material waste.
Mechanism of Action
L-Glutathione maintains redox homeostasis through multiple pathways. It directly neutralizes reactive oxygen and nitrogen species, including hydrogen peroxide, superoxide, and peroxynitrite. GSH also regenerates other antioxidants, including vitamin C, vitamin E, and coenzyme Q10, via redox cycling. It conjugates electrophilic compounds through glutathione S-transferases to form water-soluble compounds for cellular elimination. Glutathione regulates protein thiol status through glutathionylation cycles and supports the glutathione peroxidase system. Oxidized glutathione (GSSG) is recycled by glutathione reductase using NADPH. A disrupted GSH:GSSG ratio signals oxidative stress in research models.
Preclinical Research Overview
Preclinical studies confirm glutathione’s central role in oxidative protection. In liver injury models, GSH depletion predicts hepatotoxicity, whereas restoration reduces necrosis and supports cellular recovery. In ischemia-reperfusion studies, glutathione decreases lipid peroxidation. Glutathione also reduces the release of inflammatory mediators and is associated with mitochondrial function and cellular longevity in aging studies. It protects against amyloid-beta toxicity in vitro and dopaminergic neuronal loss in neurodegeneration models. Reproductive research shows improved spindle stability and reduced DNA damage, supporting glutathione’s role in oxidative resilience.
Research Use Only Disclaimer
L-Glutathione 600 mg is sold
for research use only and is not approved for human or animal consumption. No therapeutic, diagnostic, or dietary claims are made. Use only in qualified laboratory environments with institutional oversight.
Scientific References
- Lu SC. (2013). Glutathione synthesis. Biochimica et Biophysica Acta – General Subjects, 1830(5), 3143–3153. PubMed. DOI: 10.1016/j.bbagen.2012.09.008.
- Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. (2004). Glutathione metabolism and its implications for health. Journal of Nutrition, 134(3), 489–492. PubMed. DOI: 10.1093/jn/134.3.489.
- Forman HJ, Zhang H, Rinna A. (2009). Glutathione: Overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 30(1–2), 1–12. PubMed. DOI: 10.1016/j.mam.2008.08.006.
- Deponte M. (2013). Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes. Biochimica et Biophysica Acta – General Subjects. PubMed.
- Couto N, Wood J, Barber J. (2016). The role of glutathione reductase and related enzymes on cellular redox homeostasis network. Free Radical Biology and Medicine. PubMed. DOI: 10.1016/j.freeradbiomed.2016.02.028.
- National Center for Biotechnology Information. PubChem Compound Summary for Glutathione, CID 124886. PubChem.
