Overview
IGF-1 LR3 is a laboratory-synthesized form of insulin-like growth factor-1 (IGF-1). The “LR3” variant includes modifications that reduce binding to IGF-binding proteins, allowing the peptide to remain active on cell receptors for a longer period during experimental procedures. Researchers use IGF-1 LR3 to study cellular growth, tissue regeneration, and metabolic signaling in controlled laboratory and preclinical models. It is intended strictly for scientific research and is not formulated for human or veterinary use, therapeutic applications, or dietary supplementation.
Molecular Structure and Composition
IGF-1 LR3 is a synthetic peptide composed of 83 amino acids, 13 more than native IGF-1. It contains a substitution of arginine for glutamic acid at position 3 and an N-terminal extension of 13 amino acids. These modifications reduce binding to IGF-binding proteins and enhance stability during laboratory studies.
- Molecular formula: C400H625N111O115S9
- Approximate molecular weight: 9,117 Daltons
Despite these modifications, IGF-1 LR3 retains the core IGF-1 structure, enabling interaction with IGF-1 receptors in research models.
Mechanism of Action
IGF-1 LR3 binds to insulin-like growth factor-1 receptors on the cell surface, activating intracellular signaling pathways that regulate cell proliferation, survival, and metabolism. Key pathways influenced include PI3K/Akt and MAPK, which control protein synthesis, nutrient utilization, and cell division. Reduced binding to IGF-binding proteins allows prolonged receptor engagement, ensuring sustained signaling in in vitro and preclinical research models. These mechanisms are observed only in controlled laboratory and animal studies.
Research Applications
IGF-1 LR3 is applied in laboratory studies to investigate IGF signaling and its role in cell growth. Its higher stability allows sustained receptor activation over specific experimental periods. Use is limited to in vitro and preclinical research.
Cell Growth Studies
In cell culture models, IGF-1 LR3 is used to examine cellular proliferation and differentiation, tissue development, cell division rates, and structural organization of experimental tissue models.
Protein Synthesis Research
IGF-1 LR3 regulates pathways responsible for cellular protein synthesis. Studies explore how cells produce new proteins, particularly in muscle and non-muscle tissues, following experimental stress or simulated injury.
Metabolic Pathway Analysis
Researchers use IGF-1 LR3 to study interactions between growth-factor signaling and metabolic processes, including glucose uptake, lipid utilization, and energy production. These studies help clarify how IGF-1 regulates nutrient use and energy balance in controlled experiments.
Preclinical Research Applications
IGF-1 LR3 is used in animal studies to investigate tissue regeneration, organ growth, and hyperplasia. Preclinical research evaluates its effects on muscle, bone, and other tissues to study growth-factor signaling and structural development. All experiments are conducted under controlled laboratory conditions for reproducibility and consistency.
Compound Form and Specification
IGF-1 LR3 is supplied as a white lyophilized powder in sterile, sealed vials. Each vial contains 1 mg of peptide with a purity of 98–99%, verified by HPLC and mass spectrometry. Manufactured under strict laboratory conditions, the compound is free from additives unless otherwise specified.
Intended Research Use
IGF-1 LR3 is intended solely for laboratory and scientific research. It may be used in in vitro studies or approved preclinical animal models. It is not formulated for human or veterinary use, treatment, or dietary supplementation. Researchers must follow all institutional, local, and ethical guidelines when handling and conducting experiments.
Storage and Handling
Store IGF-1 LR3 as a lyophilized powder at -20°C or colder in a dark, dry environment. After reconstitution with sterile acetic acid (0.6%) or bacteriostatic water, store the solution at 4°C for short-term use (up to one week) or freeze at -20°C or lower for long-term storage. Avoid repeated freeze-thaw cycles. Always handle using proper laboratory precautions, including gloves and aseptic techniques, to maintain peptide integrity and ensure reliable experimental outcomes.
Regulatory and Safety Disclaimer
IGF-1 LR3 is provided strictly for laboratory and scientific research purposes. It has not been evaluated or approved by the FDA, EMA, or any other regulatory authority for human or animal use. Purchase and handling are restricted to trained researchers working in controlled laboratory environments. All experiments should follow institutional safety protocols, including protective equipment and responsible disposal. The manufacturer assumes no liability for misuse or use outside approved research contexts.
