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Buy VIP (Vasoactive Intestinal Peptide) – 5mg

| Third-Party Tested | 99% Purity | COA Available | Research Use Only

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide that belongs to the secretin/glucagon superfamily.

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VIP (Vasoactive Intestinal Peptide) 5mg For Sale

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide that belongs to the secretin/glucagon superfamily. VIP was first isolated in 1970 from porcine small intestine and is found widely within the central and peripheral nervous systems, gastrointestinal tract, pancreas, and immune cells. In laboratory studies, VIP is investigated for its vasodilator, secretory, anti-inflammatory, immunoregulatory, neuroprotective, and circadian regulatory properties. It is supplied as high-purity lyophilized powder (≥99% via HPLC) in 5mg vials. Made in the USA, VIP is a research compound intended for in vitro and in vivo laboratory research only, not for human consumption or any non-research therapeutic application. For research use only at Orion Peptides. Strictly not for human consumption.

Research on VIP Mechanism of Action

VIP exerts its biological effects primarily through binding to two class II G-protein-coupled receptors: VPAC1 and VPAC2. Receptor activation stimulates adenylate cyclase, increasing intracellular cyclic AMP (cAMP) and activating protein kinase A (PKA). This pathway promotes smooth muscle relaxation, increased secretion of water and electrolytes in exocrine glands, and vasodilation via nitric oxide release from endothelium. VIP inhibits pro-inflammatory cytokine production (TNF-α, IL-6, IL-12) and promotes anti-inflammatory mediators such as IL-10 and regulatory T-cell differentiation. Within the central nervous system, VIP modulates neuronal excitability, protects against excitotoxicity, and regulates suprachiasmatic nucleus activity related to circadian rhythm. These mechanisms are studied in models of inflammation, neurodegeneration, gastrointestinal motility disorders, and immune dysregulation.

VIP Peptide Sequence

VIP is a linear 28-amino acid peptide with C-terminal amidation: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

Molecular Formula

C₁₄₇H₂₃₈N₄₄O₄₂S

Molecular Weight

3325.8 Da

CAS Number

40077-57-4

PubChem CID

53314964 The C-terminal amide and specific residues (notably His¹ and Asn²⁸) are critical for receptor affinity and biological activity.

VIP Research

1. Vascular and Cardioprotective Effects

VIP is one of the strongest studied endogenous vasodilators. In isolated vascular preparations and animal models, VIP induces dose-dependent relaxation of coronary, cerebral, and mesenteric arteries through VPAC receptor–mediated cAMP elevation and nitric oxide release. In ischemia-reperfusion models, VIP has been shown to reduce infarct size, preserve endothelial function, and improve cardiac recovery.

2. Gastrointestinal Motility and Secretion

VIP modulates gut function by relaxing the esophageal sphincter, gastric fundus, and intestinal smooth muscle, while stimulating pancreatic bicarbonate and water secretion. Research indicates VIP levels influence cholinergic nerve activity and intestinal transit. Decreased expression has been associated with delayed transit in chronic intestinal pseudo-obstruction models. VIP also inhibits gastric acid secretion and enhances mucus production, making it a focus in motility and secretory disorder research.

3. Anti-Inflammatory and Immunomodulatory Actions

VIP binds to VPAC1/VPAC2 receptors on immune cells, inhibiting T-cell proliferation and pro-inflammatory cytokines such as TNF-α and IL-12, while stimulating IL-10 production. In autoimmune and inflammatory disease models (colitis, arthritis, sepsis), VIP downregulates Th1 responses and reduces tissue damage.

4. Neuroprotective and CNS Effects

In neuronal cultures and animal models, VIP protects dopaminergic neurons from oxidative stress and excitotoxicity through modulation of microglial activity and cAMP/PKA signaling. VIP also regulates circadian rhythms via VPAC2 receptors in the suprachiasmatic nucleus, influencing locomotor activity and melatonin release.

5. Motility and Microbial Interactions

Recent research highlights VIP as a mediator of microbiota effects on gut motility. VIP regulates jejunal cholinergic activity, and its levels correlate with microbial composition, suggesting a role in host-microbe communication. VIP remains investigational and is not approved for therapeutic use in humans.

How to Handle VIP 5mg

Handling Tips

  • Do not shake the vial aggressively (gently swirl only)
  • Always use sterile needles and syringes
  • Wipe the rubber stopper with alcohol before each use
  • Minimize air exposure

Important Disclaimer

VIP is an experimental research peptide intended only for in vitro or in vivo laboratory studies. It has not been evaluated or approved by the FDA, EMA, or any regulatory authority for therapeutic use. No claims are made regarding safety, efficacy, or benefit in humans. For laboratory research use only — not for human or veterinary consumption.

Referenced Citations

Research Use Only

This compound is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Molecular Formula C147H237N43O43S
Molecular Mass 3326.8 g/mol
Monoisotopic Mass 3324.7401145 Da
Polar Area 1470 Ų
Complexity 7580
XLogP -15.9
Heavy Atom Count 234
Hydrogen Bond Donor Count 51
Hydrogen Bond Acceptor Count 51
Rotatable Bond Count 115
CID 53314964
InChI InChI=1S/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1
InChIKey VBUWHHLIZKOSMS-RIWXPGAOSA-N
IUPAC Name (2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N

Certificate of Analysis

Quality

Every batch of Buy VIP (Vasoactive Intestinal Peptide) – 5mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥99%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All compounds undergo independent third-party laboratory testing for quality assurance.

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Certificate of Analysis documents are available for all compounds. Contact us with your order number to request batch-specific documentation.

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COA Lab Tests

Each compound batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the compound meets strict research-grade standards.

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Storage & Handling

Before Reconstitution (Lyophilized Powder)

Most VIP (Vasoactive Intestinal Peptide) comes in freeze-dried (lyophilized) form.

Storage Conditions:

  • Store in a refrigerator at 2°C–8°C (36°F–46°F)
  • For long-term storage, keep in a freezer at -20°C (-4°F)
  • Keep away from light
  • Keep the vial tightly sealed
  • Avoid moisture and humidity

If stored properly in freezer conditions, it can remain stable for many months.

After Reconstitution (Mixed with Bacteriostatic Water)

Once you mix VIP with bacteriostatic water:

  • Store in refrigerator at 2°C–8°C
  • Do NOT freeze after mixing
  • Keep protected from light
  • Use within 20–30 days (common peptide guideline)

Peptides are delicate. Frequent temperature changes reduce stability.

After Reconstitution (Mixed with Bacteriostatic Water)

Once you mix VIP with bacteriostatic water:

  • Store in refrigerator at 2°C–8°C
  • Do NOT freeze after mixing
  • Keep protected from light
  • Use within 20–30 days (common peptide guideline)

Peptides are delicate. Frequent temperature changes reduce stability.

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Storage

Store at -20°C.
Protect from light and moisture.

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Certificate of Analysis

ORP#00085
Client:
Orion Peptides
Sample:
VIP (Vasoactive Intestinal Peptide) 5mg
Batch:
202609VIP5
Tests Requested:
Standard + Endotoxins + Sterility
Appearance:
White Lyophilized Powder in 3mL Vial
Analysis Conducted on:
09/01/2026
Report Issued on:
09/02/2026
Test Method Result Specification  
Identity HPLC-DAD VIP VIP Pass
Purity HPLC-DAD 99.20 >99% by HPLC Pass
Quantity HPLC Analyte Concentration Curve Assay 5.05 5mg Pass
Endotoxins LAL ELISA 0.122 EU/mL ≤ 0.5 EU/mL Pass
Sterility Pour Plate No Growth No Growth Pass
Disclaimer: The data contained in this report is representative of the received sample. This analysis is for informational purposes only. The tested substances are intended for research use only and are not approved for human or veterinary use, diagnostic, therapeutic, or clinical applications. All data was obtained under standard laboratory conditions.
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