L-Carnitine 600mg For Sale
L-Carnitine is a natural quaternary ammonium compound (β-hydroxy-γ-N-trimethylaminobutyric acid) synthesized in the liver and kidneys from lysine and methionine. In the inner mitochondrial membrane, it plays an essential role in mitochondrial fatty acid β-oxidation by transporting long-chain acyl-CoA esters through the carnitine shuttle system (CPT I & II). L-Carnitine is studied for its role in energy metabolism, lipid utilization, mitochondrial function, oxidative stress, muscle bioenergetics, and age-related metabolic decline in laboratory research. Supplied as high-purity L-Carnitine base or L-Carnitine L-tartrate powder (≥99% by HPLC) in 600mg vials and bulk, produced in the USA.
For research use only at Orion peptides. Strictly not for human consumption. Biochemical Characteristics
L-Carnitine is a zwitterionic compound with a positively charged trimethylammonium moiety and negatively charged carboxylate.
Molecular formula
C₇H₁₅NO₃ (free base)
Molecular weight
161.20 Da
CAS Number
541-15-1 (L-Carnitine free base)
Appearance
White crystalline powder
Solubility
Very soluble in water (>1000 mg/mL); soluble in ethanol
pKa
Carboxyl ≈3.8, ammonium ≈8.2
Stereochemistry
Naturally produced L-enantiomer (D-isomer is pharmaceutically inactive) The quaternary ammonium allows binding to carnitine-acylcarnitine translocase for mitochondrial β-oxidation and ATP synthesis.
Research Applications
- Investigate mitochondrial fatty acid transport and β-oxidation efficiency
- Study energy metabolism in muscle, liver, and heart tissues
- Model metabolic disorders, exercise physiology, and age-related mitochondrial dysfunction
- Evaluate antioxidant and anti-inflammatory activity in oxidative stress models
- Assess neuroprotective potential in neuronal cultures and ischemia models
- Serve as control or co-treatment in lipid metabolism drug experiments
The 600mg size allows use across multiple experiments in cell culture, isolated mitochondria, organ perfusates, or small-animal metabolic studies.
Mechanism of Action
L-Carnitine transports long-chain fatty acids into mitochondria via CPT1/2 and the carnitine-acylcarnitine translocase, generating acetyl-CoA for the TCA cycle and ATP production. Additionally, L-Carnitine:
- Buffers acetyl-CoA buildup during high-fat metabolism
- Mitigates toxic acyl-CoA accumulation in metabolic diseases
- Scavenges free radicals and chelates metal ions (antioxidant role)
- Regulates membrane fluidity and stabilizes mitochondrial membranes
- Modulates fatty acid oxidation enzymes via PPAR pathways
Carnitine deficiency is linked to mitochondrial dysfunction, muscle weakness, and lipid accumulation.
Preclinical Research Summary
- In skeletal muscle and cardiac models, supplementation (0.5–2 g/kg diet or 100–500 mg/kg i.p.) increased fatty acid oxidation, reduced lactate, and improved exercise endurance in rats.
- In ischemia-reperfusion injury, L-Carnitine (200–400 mg/kg i.v.) reduced infarct size, preserved ATP, and diminished oxidative damage.
- Restores mitochondrial function, reduces lipid peroxidation, and improves metabolic flexibility in aging research.
- Protects dopaminergic neurons in neuroprotection models (Parkinson’s, Alzheimer’s) against amyloid-β toxicity.
- In vitro (1–10 mM) protects hepatocytes and myocytes from lipid overload and oxidative stress by increasing β-oxidation and reducing ROS.
- Improves insulin sensitivity and decreases visceral fat in high-fat diet rodent studies.
Form and Analytical Testing
Powder (lyophilized sterile powder or free base crystals), ≥99% purity (HPLC), identity confirmed by mass spectrometry and chiral analysis, endotoxin <0.1 EU/mg, solubility >1000 mg/mL in water, appearance: white crystalline powder, storage 2–8°C protected from light and moisture, reconstitution with sterile or bacteriostatic water under aseptic conditions, stability: 24–36 months sealed refrigerated, 1–2 weeks reconstituted at 2–8°C (avoid multiple freeze-thaw).
RUO Disclaimer
L-Carnitine 600mg is for investigational research only, suitable for in vitro or in vivo animal studies. No FDA/EMA approval for human use. Considered a research chemical (WADA S0 non-approved). Preclinical results do not guarantee human effects. Handle only in qualified labs with biosafety oversight. Not for human or veterinary consumption.
Referenced Citations
- Rebouche CJ. (2004). Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Annals of the New York Academy of Sciences.
- Pooyandjoo M, et al. (2016). Effect of L-carnitine on weight loss in adults: systematic review and meta-analysis. Obesity Reviews.
- Flanagan JL, et al. (2010). Role of carnitine in disease. Nutrition & Metabolism.
