Popular

Buy Retatrutide 20mg

Name: Buy Retatrutide Peptide 20mg |$145 only| 99% Purity|COA
SKU: RT20
Price: 145.00 USD
Availability: InStock

20mg | Third-Party Tested | 99% Purity | COA Available | Research Use Only

Retatrutide, also known as LY3437943, is an investigational synthetic peptide. Eli Lilly developed it as a triple receptor agonist. It targets GLP-1, GIP, and glucagon receptors. Researchers can now buy Retatrutide online at Orion Peptides.

$145.00

0 out of 5 · 0 ratings

Be the first to rate this compound:

41 in stock

Buy Retatrutide Peptide 20 Mg

Retatrutide, also known as LY3437943, is an investigational synthetic peptide. Eli Lilly developed it as a triple receptor agonist. It targets GLP-1, GIP, and glucagon receptors. . Researchers study retatrutide for obesity and type 2 diabetes, as well as metabolic disorders including NAFLD and MASH.Retatrutide is a long-acting popular peptide with a half-life of about six days. Research protocols use subcutaneous injection, allowing once-weekly dosing in trials. As of 2026, retatrutide remains in phase 3 clinical development under the TRIUMPH program. It is not approved by the FDA, EMA, or MHRA and is not authorized for sale, compounding, or personal use. Retatrutide is intended strictly for research, including in vitro studies, animal models, and approved human trials. It is not for off-label, veterinary, or personal consumption. Researchers can now buy Retatrutide online at Orion Peptides strictly for research purposes.

Retatrutide Mechanism of Action in Research Models

Retatrutide acts as a balanced triple agonist, binding to GLP-1, GIP, and glucagon receptors with nanomolar affinity.

Reported EC50 Values

GIP receptor: Approximately 0.064 nM GLP-1 receptor: Approximately 0.775 nM Glucagon receptor: Approximately 5.79 nM In research models, retatrutide activates multiple metabolic pathways: 1. GLP-1 receptor activation reduces appetite through central signaling, slows gastric emptying, increases glucose-dependent insulin secretion, and suppresses glucagon during hyperglycemia. 2. GIP receptor activation enhances insulin release, supports beta-cell function, and influences fat storage and metabolism. 3. Glucagon receptor activation raises energy expenditure, stimulates glycogen breakdown in the liver, promotes lipolysis and fat oxidation, and when balanced limits excess glucose elevation.

Retatrutide Peptide Structure and Properties

Property	Details
Molecular Formula	C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight	Approximately 4,731 g/mol
CAS Number	2381089-83-2
PubChem CID	171390338 (Triple G)
Amino Acid Length	39 residues

What Research Studies Say About Retatrutide

Retatrutide has shown strong results in metabolic research from preclinical studies and phase 2 trials.

1. Obesity Research

A phase 2 randomized trial published in NEJM included 338 adults with obesity or overweight and comorbidities. Once-weekly retatrutide produced dose-dependent weight loss. At 48 weeks, the 12 mg dose achieved about 24 percent weight reduction, while placebo groups showed minimal change. Over 90 percent of participants lost at least 10 percent body weight, and more than 80 percent lost at least 15 percent. Improvements were also observed in waist circumference, lipid levels, and blood pressure.

2. Type 2 Diabetes Research

Phase 2 trials reported HbA1c reductions of up to 2.02 percent. Results exceeded placebo and some comparator arms. Substantial weight loss was also observed.

3. Liver Fat and NAFLD Models

In participants with elevated liver fat, retatrutide reduced hepatic fat by over 80 percent. Many high-dose participants achieved normalization of liver fat levels.

Additional Research Areas

Phase 3 TRIUMPH trials are evaluating osteoarthritis, cardiovascular risk, kidney disease, and MASH. Some data report weight loss approaching 29 percent at 68 weeks. Pain reduction in knee osteoarthritis is also under investigation. Safety data indicate mostly mild gastrointestinal effects such as nausea, diarrhea, and vomiting. These effects are dose-related and often improve with titration. Serious hypoglycemia and major cardiac events remain rare in trials. Early findings suggest greater efficacy compared to dual agonists, positioning retatrutide as a benchmark compound in triple-hormone research.

Different Variations of Retatrutide at Orion Peptides:

Storage and Handling (Research Use Only)

Store unopened vials at 2–8°C, protected from light and moisture. Do not freeze the lyophilized powder. Reconstitute under sterile laboratory conditions using bacteriostatic water or protocol-approved diluents. Refrigerate reconstituted solutions. Use within defined stability windows and follow institutional or trial guidelines. Always utilize sterile tools and appropriate protective equipment.

Frequently Asked Questions

1. Is Orion Retatrutide Third-Party Tested?

Yes, every batch of Retatrutide we sale to researchers at Orion Peptides is third-party tested for quality and analytical specification.

2. What Does “Research Use Only” Mean for Retatrutide?

“Research use only” means our Retatrutide is supplied exclusively for legitimate scientific and laboratory research. Retatrutide is an investigational compound and is not approved for human consumption, self-administration, veterinary use, or off-label use. Our compounds are intended for qualified research applications only.

3. Where Can I Buy Retatrutide for Research?

You can buy Retatrutide for research from Orion Peptides. We provide Retatrutide as a research-use compound with third-party testing and batch-specific documentation. Researchers can review the available compound information and COA before placing an order.

4. Is Retatrutide FDA Approved?

No. Retatrutide remains an investigational compound and is not FDA approved. It is currently being studied in clinical development, including the Phase 3 TRIUMPH program. It is not approved for personal use or general consumption.

5. Can I Get Fast Shipping When I Buy Retatrutide?

Yes. Orion Peptides offers fast shipping options for research compounds, including Overnight and two-day shipping where available. Shipping times can vary depending on the destination and selected shipping method.

6. Can I View the Retatrutide Certificate of Analysis (COA) Before Buying?

Yes. Orion Peptides provides a Certificate of Analysis (COA) for Retatrutide so researchers can review the testing results before purchasing. Each COA contains batch-specific analytical information, including the reported purity and testing results for that specific batch.

7. Why Should I Choose Orion Peptides for Retatrutide?

Orion Peptides provides Retatrutide for legitimate research purposes with third-party testing and batch-specific Certificates of Analysis. Researchers can review compound specifications and available testing documentation before purchasing, helping them make an informed decision about their research materials.

Disclaimer

Retatrutide is an investigational research compound and remains in phase 3 clinical trials as of 2026. It is not approved for prescription or commercial use. Compounds marketed outside regulated clinical trials may be counterfeit and pose serious safety risks. Clinical and preclinical data do not guarantee regulatory approval. No claims are made regarding safety or efficacy at Orion Peptides. Use is limited to qualified research settings. Regulatory restrictions may apply.

Referenced Citations

Jastreboff AM, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine. doi:10.1056/NEJMoa2301972.
Katsi V, et al. (2025). Retatrutide—A Game Changer in Obesity Pharmacotherapy. PMC review synthesizing phase 1/2 data.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12026077/

Research Use Only

This compound is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Property	Value
Molecular Formula	C221H342N46O68
Molecular Mass	4731 g/mol
Monoisotopic Mass	4728.4717592 Da
Polar Surface Area	1780 Å²
Complexity	11500
XLogP	-6.3
Heavy Atom Count	335
Hydrogen Bond Donor Count	58
Hydrogen Bond Acceptor Count	70
Rotatable Bond Count	159
PubChem CID	171390338
InChI	InChI=1S/C221H342N46O68/c1-23-124(11)179(208(322)241-144(83-88-176(291)292)192(306)245-150(105-134-69-75-137(276)76-70-134)196(310)244-148(100-121(5)6)194(308)243-147(99-120(3)4)193(307)240-142(82-87-175(289)290)187(301)230-110-169(282)229-113-173(286)264-92-51-61-161(264)206(320)253-158(116-270)203(317)251-157(115-269)189(303)232-111-170(283)233-128(15)212(326)266-94-53-63-163(266)214(328)267-95-54-64-164(267)213(327)265-93-52-62-162(265)207(321)250-156(114-268)183(226)297)258-200(314)152(103-131-55-41-39-42-56-131)242-185(299)127(14)235-216(331)219(18,19)262-205(319)145(80-85-166(225)279)237-184(298)126(13)234-190(304)140(60-48-50-90-227-172(285)119-335-98-97-334-96-91-228-167(280)86-81-146(215(329)330)236-168(281)65-45-37-35-33-31-29-27-25-26-28-30-32-34-36-38-46-66-174(287)288)238-191(305)141(59-47-49-89-222)239-198(312)154(107-177(293)294)247-195(309)149(101-122(7)8)256-218(333)221(22,109-123(9)10)263-211(325)180(125(12)24-2)259-204(318)160(118-272)252-197(311)151(106-135-71-77-138(277)78-72-135)246-199(313)155(108-178(295)296)248-202(316)159(117-271)254-210(324)182(130(17)274)260-201(315)153(104-132-57-43-40-44-58-132)249-209(323)181(129(16)273)257-171(284)112-231-188(302)143(79-84-165(224)278)255-217(332)220(20,21)261-186(300)139(223)102-133-67-73-136(275)74-68-133/h39-44,55-58,67-78,120-130,139-164,179-182,268-277H,23-38,45-54,59-66,79-119,222-223H2,1-22H3,(H2,224,278)(H2,225,279)(H2,226,297)(H,227,285)(H,228,280)(H,229,282)(H,230,301)(H,231,302)(H,232,303)(H,233,283)(H,234,304)(H,235,331)(H,236,281)(H,237,298)(H,238,305)(H,239,312)(H,240,307)(H,241,322)(H,242,299)(H,243,308)(H,244,310)(H,245,306)(H,246,313)(H,247,309)(H,248,316)(H,249,323)(H,250,321)(H,251,317)(H,252,311)(H,253,320)(H,254,324)(H,255,332)(H,256,333)(H,257,284)(H,258,314)(H,259,318)(H,260,315)(H,261,300)(H,262,319)(H,263,325)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,295,296)(H,329,330)/t124-,125-,126-,127-,128-,129+,130+,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,179?,180?,181-,182-,221+/m0/s1
InChIKey	MLOLQJNKXBNWFW-SAGGEDDASA-N
IUPAC Name	20-[[(1S)-4-[2-[2-[2-[[(5S)-5-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-2,4-dimethylpentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-6-[[(2S)-1-[[(2S)-5-amino-1-[[1-[[(2S)-1-[[(2S)-1-[[(3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid
SMILES	CC[C@H](C)C(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC6=CC=CC=C6)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](C)(CC(C)C)NC(=O)C([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CC=C(C=C7)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)C(C)(C)NC(=O)[C@H](CC9=CC=C(C=C9)O)N

Certificate of Analysis

Quality

Every batch of Buy Retatrutide 20mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥99%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All compounds undergo independent third-party laboratory testing for quality assurance.

Request COA

Certificate of Analysis documents are available for all compounds. Contact us with your order number to request batch-specific documentation.

COA Lab Tests

Each compound batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the compound meets strict research-grade standards.

Storage & Handling

Before Use (Uno⁠pened)

Store i‍n refri‌gerator at 2⁠°C‍ to 8°C, equivalent to‍ 36°F t‍o 46‌°F tem⁠perature r‌ange
Keep temperature consisten⁠t at a⁠ll‌ times

Store i‍n the main refrigerator compartment, avoid storing in the refrigerat⁠or do⁠or

‍Keep in o⁠ri⁠ginal p⁠a⁠c‍k⁠ag‌ing⁠ always

A‌fter Reconst‌itution (Liquid Form)

Continu⁠e⁠ refrigerat⁠ing⁠ at 2°‍C to 8°C⁠, 36°F and 46°F consistently
Ke‍ep the liquid form refrigerate‍d between dose‍s
R‌eturn to refrigerator immediately after use

Storage During Travel‌

‍Keep‌ in original packaging
Minimize time outside p‍roper storage
Retu⁠rn t⁠o refrigerator promptly upon arrival
Plan ahead for ext‍ended trav‌el

A‌fter Reconst‌itution (Liquid Form)

Continu⁠e⁠ refrigerat⁠ing⁠ at 2°‍C to 8°C⁠, 36°F and 46°F consistently
Ke‍ep the liquid form refrigerate‍d between dose‍s
R‌eturn to refrigerator immediately after use

Add

Test	Method	Result	Specification
Identity	HPLC-DAD	Retatrutide	Retatrutide	Pass
Purity	HPLC-DAD	99.46	>99% by HPLC	Pass
Quantity	HPLC Analyte Concentration Curve Assay	20.36	20mg	Pass
Endotoxins	LAL ELISA	0.136 EU/mL	≤ 0.5 EU/mL	Pass
Sterility	Pour Plate	No Growth	No Growth	Pass

Buy Retatrutide 20mg

Bulk Pricing – Save More

Buy Retatrutide Peptide 20 Mg

Retatrutide Mechanism of Action in Research Models

Reported EC50 Values

Retatrutide Peptide Structure and Properties

What Research Studies Say About Retatrutide

1. Obesity Research

2. Type 2 Diabetes Research

3. Liver Fat and NAFLD Models

Additional Research Areas

Different Variations of Retatrutide at Orion Peptides:

Storage and Handling (Research Use Only)

Frequently Asked Questions

1. Is Orion Retatrutide Third-Party Tested?

2. What Does “Research Use Only” Mean for Retatrutide?

3. Where Can I Buy Retatrutide for Research?

4. Is Retatrutide FDA Approved?

5. Can I Get Fast Shipping When I Buy Retatrutide?

6. Can I View the Retatrutide Certificate of Analysis (COA) Before Buying?

7. Why Should I Choose Orion Peptides for Retatrutide?

Disclaimer

Referenced Citations

Research Use Only

Chemical Properties

Certificate of Analysis

Quality

HPLC Analysis

Mass Spectrometry (MS)

Third-Party Testing

Request COA

COA Lab Tests

Storage & Handling

Before Use (Uno⁠pened)

A‌fter Reconst‌itution (Liquid Form)

Storage During Travel‌

A‌fter Reconst‌itution (Liquid Form)

Related Compounds

Storage

Certificate of Analysis